상악동 거상술에서 rhBMP-2의 사용이 골형성에 미치는 효과에 대한 임상 및 방사선학적 연구
A clinical & radiologic study of bone remodeling effects using rhBMP-2 for maxillary sinus graft
김정호, 김욱천, 이장렬, 김현철, 김수남,
소속 상세정보
김정호 ( Kim Jung-Ho ) - 리빙웰치과병원 구강악안면외과
김욱천 ( Kim Uk-Cheon ) - 리빙웰치과병원 구강악안면외과
이장렬 ( Lee Jang-Yeol ) - 리빙웰치과병원 구강악안면방사선과
김현철 ( Kim Hyun-Chull ) - 리빙웰치과병원 구강악안면외과
김수남 ( Kim Soo-Nam ) - 리빙웰치과병원 구강악안면외과
KMID : 1025720160350020046
Abstract
Purpose: The aim of this study is to evaluate effects using rhBMP-2 for maxillary sinus graft, especially focused on loading time and stability of postoperative period.
Materials and Methods: 73 partially or completely edentulous patients who have been treated in Livingwell dental hospital between 2011 to 2015 with atrophic maxillary posterior were selected. Crestal and lateral approach were used for sinus floor elevation procedure. A total of 116 implants-Tapered Screw Vent implant (Zimmer, USA), TS3 (Osstem, Korea), CMI IS-II active (Neobiotech, Korea)-were placed in grafted maxillary sinus. The rhBMP-2 (Cowell BMP; Cowellmedi inc. Korea, Novosis; Daewoong co. Inc. Korea) mix to demineralized dentin matrix (DDM), allograft (CG-Oss, CGBio, Korea) or ??TCP (CERASORBⓡ, Curasan, Germeny) was grafted into sinus mainly. We spin the RFA values as the basis for determining the loading time. If the ISQ value at day to load were ＜65, we wait, and the ISQ values was measured again 1 weeks later until the required level is reached. Panoramic radiographs or CBCT were taken preoperatively, postoperatively (1 day after operation, T0), and then at yearly intervals (1 year after surgery: T1, 2 year after surgery: T2, 3 years after
surgery: T3) for evaluate the peri-implant bone and maxillary sinuses.
Results: 5 implants failed due to infection and 2 implants lost to follow up. The average preoperatively height of the maxillary alveolar bone was 5.17±3.28 mm, and minimum was 0.1 mm. The Mean period to load implants was 142.33±40.48 days, and minimum was 56 days. The average HGB was 2.12±0.94 mm at T1, 1.53±0.61 mm at T2, 1.22±0.72 mm at T3. The average resorption rate of HGB was 28.33±14.59% at T1, 37.28±16.99% at T2, 37.75±17.02% at T3. Statistical analysis was performed with postoperative data of T1 period. There are no significant difference of resorption rate (p-value=0.83) between early loading group (27.87±13.86%) and conventional loading group (28.82±15.67%).
Conclusions: The result indicated that using rhBMP-2 for maxillary sinus graft could shorten the loading time stably.
키워드
Sinus graft; rhBMP-2; DDM
원문 및 링크아웃 정보
등재저널 정보